AZD-2327

• Description:

  AZD-2327 is a potent and selective δ-opioid receptor agonist. AZD-2327 binds to the human opioid receptor (Ki = 0.49 and 0.75 nM and EC50 = 24 and 9.2 nM at the C27 and F27 isoforms, respectively) . AZD-2327 shows selectivity of >1000-fold over the human μ- and κ-opioid receptor subtypes as well as >130 other receptors and channels. AZD-2327 exhibits antidepressant and anxiolytic activities and can be used for the research of neurological disease[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301-H361

• Target:

  Opioid Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  CCN(CC)C(C(C=C1)=CC=C1[C@H](C2=CC(N)=CC=C2)N3CCN(CC4=CC=C(F)C=C4)CC3)=O

• Molecular Formula:

  C29H35FN4O

• Molecular Weight:

  474.61

• Precautions:

  P264-P270-P330-P405-P501

• References & Citations:

  [1]Hudzik TJ, et al. Preclinical pharmacology of AZD2327: a highly selective agonist of the δ-opioid receptor. J Pharmacol Exp Ther. 2011 Jul;338 (1) :195-204.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  δ Opioid Receptor/DOR

• CAS Number:

  [875647-81-7]