Atomoxetine-d7

• Description :

  Atomoxetine-d7 (Tomoxetine-d7) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

• Product Name Alternative :

  Tomoxetine-d7; (R) -Tomoxetine-d7

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; Serotonin Transporter; Sodium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease; Cancer

• Smiles :

  [2H]C([2H])([2H])C(C([2H])=C([2H])C([2H])=C1[2H])=C1O[C@@H](C2=CC=CC=C2)CCNC

• Molecular Formula :

  C17H14D7NO

• Molecular Weight :

  262.40

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. |[3]Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489.|[4]Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27 (5) :699-711.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [919104-07-7]