Atomoxetine (hydrochloride) (Standard)

Atomoxetine (hydrochloride) (Standard)

• CAS Number: 82248-59-7
• UNSPSC Description: Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].
• Target Antigen: Adrenergic Receptor; Serotonin Transporter; Sodium Channel
• Type: Reference Standards
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/atomoxetine-hydrochloride-standard.html
• Smiles: CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl
• Molecular Weight: 291.82
• References & Citations: [1]Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. |[2]Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489.|[3]Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.
• Shipping Conditions: Room temperature