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Atomoxetine

CAT: 0804-HY-107370Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107370Size:1 Each
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Description
Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].
CAS Number
83015-26-3
Product Name Alternative
Tomoxetine; (R) -Tomoxetine
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Serotonin Transporter; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/atomoxetine.html
Solubility
10 mM in DMSO
Smiles
CC(C=CC=C1)=C1O[C@@H](C2=CC=CC=C2)CCNC
Molecular Formula
C17H21NO
Molecular Weight
255.35
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. |[2]Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489.|[3]Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27 (5) :699-711.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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