TP-9201

CAT: 0804-HY-106394Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-106394Size:1 Each

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Description

TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) -induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis[1].

CAS Number

138297-15-1

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)NC(C)=O)C(N)=O)=O)CCCNC(N)=N)=O)CC3=CC=C(C=C3)OC)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O

Molecular Formula

C45H69N17O14S2

Molecular Weight

1136.26

References & Citations

[1]Rebello SS, et al. TP-9201, a glycoprotein IIb/IIIa platelet receptor antagonist, prevents rethrombosis after successful arterial thrombolysis in the dog. Stroke. 1997 Sep;28 (9) :1789-96.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

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