TP-9201

• Description :

  TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918) -induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM) . TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis[1].

• UNSPSC :

  12352005

• Target :

  P-glycoprotein

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)NC(C)=O)C(N)=O)=O)CCCNC(N)=N)=O)CC3=CC=C(C=C3)OC)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O

• Molecular Formula :

  C45H69N17O14S2

• Molecular Weight :

  1136.26

• References & Citations :

  [1]Rebello SS, et al. TP-9201, a glycoprotein IIb/IIIa platelet receptor antagonist, prevents rethrombosis after successful arterial thrombolysis in the dog. Stroke. 1997 Sep;28 (9) :1789-96.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [138297-15-1]