FK 973

• Description:

  FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research[1][2].

• UNSPSC:

  12352005

• Target:

  DNA Alkylator/Crosslinker; DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  CC(O[C@]12[C@@H]3[C@H](C[N@@](C4=CC(C=O)=CC(OC(C)=O)=C4[C@@H]2COC(N)=O)O1)N3C(C)=O)=O

• Molecular Formula:

  C20H21N3O9

• Molecular Weight:

  447.40

• References & Citations:

  [1]Shimizu K, et al. [Antitumor efficacy of FK 973 on malignant glioma cells]. Gan To Kagaku Ryoho. 1989 Jul;16 (7) :2367-72. Japanese.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  114580-45-9