T 162559

• Description:

  T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease[1].

• UNSPSC:

  12352005

• Target:

  Na+/H+ Exchanger (NHE)

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  CS (=O) (O) =O.CS (=O) (O) =O.CC1=C ([C@@H]2C/C (C3=C (C) C=CN=C3C2) =N\NC (N) =N) C=C (F) C=C1

• Molecular Formula:

  C20H28FN5O6S2

• Molecular Weight:

  517.59

• References & Citations:

  [1]Kawamoto T, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001 May 18;420 (1) :1-8.|[2]Kusumoto K, et al. In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. Br J Pharmacol. 2002 Apr;135 (8) :1995-2003.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  339532-12-6