T 162559

• Description :

  T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease[1].

• UNSPSC :

  12352005

• Target :

  Na+/H+ Exchanger (NHE)

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  CS(=O)(O)=O.CS(=O)(O)=O.CC1=C([C@@H]2C/C(C3=C(C)C=CN=C3C2)=N\NC(N)=N)C=C(F)C=C1

• Molecular Formula :

  C20H28FN5O6S2

• Molecular Weight :

  517.59

• References & Citations :

  [1]Kawamoto T, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001 May 18;420 (1) :1-8.|[2]Kusumoto K, et al. In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. Br J Pharmacol. 2002 Apr;135 (8) :1995-2003.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [339532-12-6]