TP-061

• Description:

  Brr2-IN-2 (Compound 30) is a Brr2 inhibitor with an IC50 of 42 nM for Brr2 ATPase[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Smiles:

  O=C1NC2=C(C=C(F)C=C2)[C@]13N(C(C4=CN(C)C=N4)=O)[C@@H](CC(C)C)C[C@H]3C

• Molecular Formula:

  C21H25FN4O2

• Molecular Weight:

  384.45

• References & Citations:

  [1]Ito M, et al. Discovery of spiro[indole-3,2'-pyrrolidin]-2 (1H) -one based inhibitors targeting Brr2, a core component of the U5 snRNP. Bioorg Med Chem. 2017 Sep 1;25 (17) :4753-4767.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2133440-09-0]