Products for Research Use Only
RegisterLogin

YKL-06-061

CAT: 0804-HY-120056-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120056-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1].
CAS Number
2172617-15-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ykl-06-061.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C1N(C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)C)=NC=C2CN1C5=C(C=CC=C5C)C)C6CCC6
Molecular Formula
C30H37N7O2
Molecular Weight
527.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19 (11) :2177-2184.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIK1

Chemical Information

1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
CAS Number2172617-15-9
PubChem CID132992144
IUPAC Name1-cyclobutyl-3-(2,6-dimethylphenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one
Molecular FormulaC30H37N7O2
Molecular Weight527.7
XLogP4.5
Topological Polar Surface Area77.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count39
Formal Charge0
Complexity824
SMILES
CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC
InChI
InChI=1S/C30H37N7O2/c1-20-7-5-8-21(2)27(20)36-19-22-18-31-29(33-28(22)37(30(36)38)23-9-6-10-23)32-25-12-11-24(17-26(25)39-4)35-15-13-34(3)14-16-35/h5,7-8,11-12,17-18,23H,6,9-10,13-16,19H2,1-4H3,(H,31,32,33)
InChIKey
GVBAXIVNAHMIGH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
CAS: 2172617-15-9
CID: 132992144
Formula: C30H37N7O2
MW: 527.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight527.7
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass527.30087345
Monoisotopic Mass527.30087345
Topological Polar Surface Area77.1 Ų
Heavy Atom Count39
Formal Charge0
Complexity824
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-129141-01YKL-06-062
HY-103041TP-061
HY-112929-01DT-061
HY-101149YKL-05-093
HY-116871-01YKL-1-116
HY-101147-01YKL-05-099
HY-112929B-01(1S,2S,3R) -DT-061
HY-101257-01YKL-5-124
HY-115805YKL-04-085
HY-149760-01PVD-06

Alternative Products

CatalogName
BA6252-10YKL-06-061
MBS3603473-01YKL 06-061
A18836-50YKL-06-061 50mg
A18836-10YKL-06-061 10mg
A18836-500YKL-06-061 500mg
A18836-100YKL-06-061 100mg
A18836-25YKL-06-061 25mg
A18836-5YKL-06-061 5mg
A18836-1YKL-06-061 1mg
XLD61716-01YKL-06-062

Popular Products