Tz-Thalidomide (Standard)

• Description :

  Tz-Thalidomide (Standard) is the analytical standard of Tz-Thalidomide (HY-101460) . This product is intended for research and analytical applications. Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase) . Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2) . Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].

• Target :

  Epigenetic Reader Domain; Molecular Glues; PROTACs; Reference Standards

• Related Pathways :

  Epigenetics; Others; PROTAC

• Field of Research :

  Cancer

• Smiles :

  O=C(CCCCCOC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1)NCC(C=C4)=CC=C4C5=NN=C(C)N=N5

• Molecular Formula :

  C29H29N7O6

• Molecular Weight :

  571.58

• References & Citations :

  [1]Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2 (12) :927-934.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [2087490-42-2]