Granulins rabbit pAb

CAT: 0855-ES20441-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES20441-01Size:50 µL

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Background

Disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease., function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth., function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling., PTM:Granulins are disulfide bridged., similarity:Belongs to the granulin family., tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

Description

Disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM: 607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. function: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. PTM: Granulins are disulfide bridged. similarity: Belongs to the granulin family. tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

UniProt

P28799

Swiss Prot

P28799

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human Granulins AA range: 520-600

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Secreted . Lysosome . Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925) . Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925) . Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity) . .

Other Product Names

Granulins (Proepithelin; PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G) ; Granulin-2 (Granulin F) ; Granulin-3 (Granulin B) ; Granulin-4 (Granulin A) ; Granulin-5 (Granulin C) ; Granulin-6 (Granulin D) ; Granulin-7 (Granulin E) ]

Gene ID (Human)

2896

UniProtKB · P28799

Progranulin

GRN_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P28799
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GRN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PGRN
EC number: —
Processing: Precursor
Secondary accessions: D3DX55, P23781, P23782, P23783, P23784, Q53HQ8, Q53Y88, Q540U8, Q9BWE7, Q9H8S1, Q9UCH0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Cellular component

LysosomeSecreted

Disease

NeurodegenerationNeuronal ceroid lipofuscinosis

Domain

RepeatSignal

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