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LZFPN-90

CAT: 0804-HY-162519Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162519Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LZFPN-90 (LZ90) is a dual NAMPT/PD-L1 targeting compound. LZFPN-90 inhibits PD-1/PD-L1 interaction and NAMPT activity. LZFPN-90 inhibits cell growth in a NAMPT-dependent manner and blocks the cell cycle, subsequently inducing apoptosis. LZFPN-90 exerted target-dependent antitumor activities, affecting metabolic processes and the immune system[1].
Product Name Alternative
LZ90
UNSPSC
12352005
Target
Apoptosis; NAMPT; PD-1/PD-L1
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lzfpn-90.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(CN/C(NC2=CC=NC=C2)=N\C#N)S1)N(CC3)C4=C3C(C5=CC=CC(OCCCN(CC)CC)=C5)=CC=C4
Molecular Formula
C33H36N8O2S
Molecular Weight
608.76
References & Citations
[1]Yang Y, et al. The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor. EMBO Mol Med. 2024 Apr;16 (4) :885-903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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