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IRE1α rabbit pAb

CAT: 0855-ES20512-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20512-01Size:50 µL
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Background
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008],
UniProt
O75460
Swiss Prot
O75460
Reactivity
Human; Mouse; Rat
Immunogen
Purified recombinant fragment of human IRE1α (aa282-433) expressed in E. Coli.
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Other Product Names
ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
Gene ID (Human)
2081

UniProtKB · O75460

Serine/threonine-protein kinase/endoribonuclease IRE1

ERN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75460
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A1L457, A8K8N8, A8MXS7, Q59EE2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationDisulfide bondGlycoproteinPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulationUnfolded protein response

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Endoplasmic reticulumMembrane

Molecular function

HydrolaseKinaseMultifunctional enzymeSerine/threonine-protein kinaseTransferase

Domain

SignalTransmembraneTransmembrane helix

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