ACT-660602

CAT: 0804-HY-151096-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-151096-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ACT-660602 is an orally active antagonist of chemokine receptor (CXCR3) with an IC50 value of 204 nM. ACT-660602 inhibits T-cell migration and shows efficacy in acute lung ingury model. ACT-660602 can be used for autoimmune diseases research[1][2].
CAS Number
[1646267-59-5]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/act-660602.html
Purity
99.02
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
FC(C1=NC=C(C2=C(N3C[C@@H](C)N(C(CN4N=C(C)N=C4C)=O)CC3)SC(C(F)(F)F)=N2)C=N1)(F)F
Molecular Formula
C20H20F6N8OS
Molecular Weight
534.48
References & Citations
[1]Meyer EA, et al. Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases. J Med Chem. 2022 Aug 10.|[2]Caroff Eva, et al. Preparation of piperazinyltriazolylethanone derivatives for use as CXCR3 receptor modulators: World Intellectual Property Organization, WO2015011099. 2015-01-29.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR3

Related Products

CatalogName
HY-124071-01ACT-389949
HY-101834-01ACT-462206
HY-153240ACT-672125
HY-119085ACT-281959
HY-108683ACT-335827
HY-149055-01ACT-777991
HY-111817-01ACT-451840
HY-U00262ACT 178882
HY-12616ACT-209905
HY-118036ACT-387042

Alternative Products

CatalogName
BA5305-5.1ACT-660602
YP-W16964-01Human ACT (ACT) ELISA Kit
MBS132402-01Macitentan (ACT 064992; ACT-064992)
MBS3613109-01ACT-389949
M12099-01ACT-541468
MBS3840044-01ACT-335827
4983/10ACT 335827
MBS5765572ACT-678689
MBS5776286ACT-209905
571533ACT-451840

Popular Products