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PT-ttpy

CAT: 0931-TYD-01841-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-01841-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
727721-37-1
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
Pt-ttpy is a metallo-organic compound and an effective G-quadruplex ligand that efficiently induces significant telomere-associated DNA damage in cancer cells by inhibiting telomerase and/or telomere function. It also causes various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFB), and double-stranded breaks (DSB) .
Molecular Formula
C22H17Cl2N3Pt
Molecular Weight
589.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

PT-ttpy
CAS Number727721-37-1
PubChem CID162393732
IUPAC Namechloroplatinum;4-(4-methylphenyl)-2,6-dipyridin-2-ylpyridine;chloride
Molecular FormulaC22H17Cl2N3Pt-
Molecular Weight589.4
Topological Polar Surface Area38.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count28
Formal Charge-1
Complexity390
SMILES
CC1=CC=C(C=C1)C2=CC(=NC(=C2)C3=CC=CC=N3)C4=CC=CC=N4.[Cl-].Cl[Pt]
InChI
InChI=1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+1/p-2
InChIKey
ARVAWSYKUVYZLC-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of PT-ttpy
CAS: 727721-37-1
CID: 162393732
Formula: C22H17Cl2N3Pt-
MW: 589.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight589.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass588.044747
Monoisotopic Mass588.044747
Topological Polar Surface Area38.7 Ų
Heavy Atom Count28
Formal Charge-1
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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