PT-65

• Target :

  Others|||GSK-3|||PROTACs

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Others|||Stem Cells|||PROTAC

• Bioactivity :

  PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3? (DC50 = 28.3 nM) and GSK3? (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].

• Smiles :

  O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCCOCCN4C=C(CCCCN5CCN(S(=O)(=O)C6=CC=C(C=C6)C7=NC(C(NC=8C=CC=NC8)=O)=C(N)N=C7)CC5)N=N4

• Molecular Formula :

  C51H63N13O12S

• Molecular Weight :

  1082.19

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2721998-87-2