Cys-PKHB1

CAT: 0931-TP3757-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TP3757-01Size:10 mg
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CAS Number
2378833-51-1
Target
Others|||ROS|||Thrombopoietin Receptor
Related Pathways
Others|||Immunology/Inflammation
Bioactivity
Cys-PKHB1 (Cys-txCD47) is a polypeptide consisting of a cysteine (Cys) residue coupled with PKHB1, which is a CD47 agonist peptide that acts as a thrombospondin-1 peptide mimetic with anti-tumor properties. In breast cancer cells, PKHB1 induces mitochondrial changes, ROS production, intracellular Ca+ accumulation, and calcium-dependent cell death. Additionally, PKHB1 activates the immune system by inducing immunogenic cell death in breast cancer cells.
Smiles
C([C@@H](C(N[C@H](C(N[C@H](CCCCN)C(O)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](NC([C@H](CS)N)=O)CCCCN)=O)CCCNC(=N)N)=O)=O)=O)C(C)C)=O)[C@H](C)C)=O)CCSC)=O)C=3C=4C(NC3)=CC=CC4
Molecular Formula
C71H110N18O13S2
Molecular Weight
1487.88
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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