Cys-PKHB1

• Target:

  Others|||ROS|||Thrombopoietin Receptor

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  Cys-PKHB1 (Cys-txCD47) is a polypeptide consisting of a cysteine (Cys) residue coupled with PKHB1, which is a CD47 agonist peptide that acts as a thrombospondin-1 peptide mimetic with anti-tumor properties. In breast cancer cells, PKHB1 induces mitochondrial changes, ROS production, intracellular Ca+ accumulation, and calcium-dependent cell death. Additionally, PKHB1 activates the immune system by inducing immunogenic cell death in breast cancer cells.

• Smiles:

  C ([C@@H] (C (N[C@H] (C (N[C@H] (CCCCN) C (O) =O) =O) CCCCN) =O) NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC1=CC=C (O) C=C1) NC ([C@H] (CC2=CC=CC=C2) NC ([C@@H] (NC ([C@H] (NC ([C@H] (CS) N) =O) CCCCN) =O) CCCNC (=N) N) =O) =O) =O) C (C) C) =O) [C@H] (C) C) =O) CCSC) =O) C=3C=4C (NC3) =CC=CC4

• Molecular Formula:

  C71H110N18O13S2

• Molecular Weight:

  1487.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2378833-51-1