PKHB1

• Target :

  Reactive Oxygen Species|||Thrombopoietin Receptor

• Related Pathways :

  Metabolism|||Immunology/Inflammation|||NF-?B

• Bioactivity :

  PKHB1 is a thrombospondin-1 peptide mimetic known for its antitumor properties. It induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. Additionally, PKHB1 promotes immune system activation through immunogenic cell death in breast cancer cells.

• Smiles :

  C([C@@H](C(N[C@H](C(N[C@H](CCCCN)C(O)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](CCCCN)N)=O)CCCNC(=N)N)=O)=O)=O)C(C)C)=O)[C@H](C)C)=O)CCSC)=O)C=3C=4C(NC3)=CC=CC4

• Molecular Formula :

  C68H105N17O12S

• Molecular Weight :

  1384.73

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1505523-99-8