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TAT-PiET-PROTAC

CAT: 0931-TP3563-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3563-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
TAT-PiET-PROTAC is a TAT-PiET modified by a proteolysis targeting chimera (PROTAC) . TAT-PiET is a cell-penetrating peptide that targets the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC disrupts the interaction between BRD4 and the oncogene JMJD6 in breast cancer, effectively inhibiting the growth of these cancer cells. Additionally, it combats endocrine resistance in ERα-positive breast cancer cells, making it a promising breast cancer inhibitor. TAT-PiET-PROTAC is also utilized in the synthesis/research of radiolabeled conjugate drugs (RDC) .
Molecular Formula
C145H239N53O35S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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