TAT-PiET

CAT: 0931-TP2673-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TP2673-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3036046-03-1

Target

Epigenetic Reader Domain

Related Pathways

Chromatin/Epigenetic

Bioactivity

TAT-PiET, a cell-penetrating peptide, targets the extra-terminal (ET) domain of BRD4, disrupting the critical BRD4/JMJD6 protein complex interaction necessary for oncogene expression in breast cancer. By inhibiting BRD4/JMJD6 target gene expression, TAT-PiET effectively suppresses breast cancer cell growth and confers resistance to endocrine therapy in ERα-positive breast cancer cells, marking it as a potential inhibitor of breast cancer.

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[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)CS)=O)CCCCN)=O

Molecular Formula

C110H192N48O27S

Molecular Weight

2651.07

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-P10445	TAT-PiET
HY-P10446	TAT-PiET-PROTAC
068-27	TAT Derivative, R9-Tat
abx600294-01	Protein Tat (TAT) Protein
HY-P0281-01	TAT
E8ER1919-19	α-TAT
CRB1001142-01	TAT - GluR23Y - (TAT Conjugated Peptides)

TAT-PiET

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