SBI-810

• Target:

  Neurotensin Receptor

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  SBI-810 is a functional selective ?-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1) . In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.

• Smiles:

  OCCN(C=1C=CC=2N=C(N=C(C2C1)N3CCC(C=4C=CC=CC4OC)CC3)C5(C)CC5)C

• Molecular Formula:

  C27H34N4O2

• Molecular Weight:

  446.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1849603-79-7