AKI-001

CAT: 0931-T68332-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68332-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

925218-37-7

Target

Others

Related Pathways

Others

Bioactivity

AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.

Smiles

C(C)N1C=2C=C3C4=C(NC3=CC2C(C)(C)C1=O)C=5C(CCC4)=C(C)NN5

Molecular Formula

C21H24N4O

Molecular Weight

348.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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AKI-001

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