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GABAA receptor modular-3

CAT: 0931-T88717-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88717-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3021554-08-2
Target
GABA Receptor
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Bioactivity
Compound S28, also known as GABAA receptor modulator-3, regulates the (γ-aminobutyric acid) A receptor (GABAA receptor), exhibiting EC50 values of 56 nM for the α1β2γ2 subtype and 10 nM for the α4β3δ subtype. In rats, it demonstrates favorable pharmacokinetic properties and slight toxicity. The threshold dose for loss of righting reflex (LORR) in rats is 23.3 μmol/kg. Furthermore, Compound S28 shows potential to alleviate postpartum depression.
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C[C@@]12[C@]([C@]3([C@@]([C@@]4([C@](CC3)(C[C@](C)(O)CC4)[H])[H])(CC1)[H])[H])(CC[C@@H]2C(CN5C(=O)N(N=C5)C=6C=C(F)N=C(F)C6)=O)[H]
Molecular Formula
C28H36F2N4O3
Molecular Weight
514.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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