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GABAA receptor modulator-9

CAT: 0931-T211847-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211847-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
GABA Receptor
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Bioactivity
GABAA receptor modulator-9 is a positive allosteric modulator of the GABAA receptor, specifically targeting the α1β2γ2 subtype and capable of crossing the blood-brain barrier. It exhibits excellent activity at α1β2γ2 (EC50: 0.9 μM in oocytes and 0.2 μM in CHO cells) and also shows activity at α1β2, α3β2γ2, and α1β3γ2 (with EC50 values of 1.3, 3.4, and 1.1 μM, respectively) . GABAA receptor modulator-9 significantly inhibits seizure progression and reduces mortality in mice. It is applicable in studies of status epilepticus (SE) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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