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KT-333 diammonium

CAT: 0931-T88365-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88365-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2502186-80-1
Target
Molecular Glues, STAT
Related Pathways
Stem Cells, PROTAC, JAK/STAT signaling
Bioactivity
KT-333 diammonium functions as a molecular glue that targets and degrades the STAT3 protein. It selectively mediates the degradation of STAT3 via the ubiquitin-proteasome pathway by attaching to STAT3 and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL) . This compound exhibits strong specificity in degrading STAT3 and demonstrates significant antitumor activity. KT-333 diammonium is applicable in researching hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) .
Smiles
ClC(C(CCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=CC=C4)=C4OC[C@H](CCC(N)=O)NC([C@H]5N6[C@](CCN(C[C@@H](C6=O)NC(C7=CC8=CC(C(P([O-])([O-])=O)=O)=CC=C8N7)=O)C(C)=O)([H])CC5)=O.[NH4+].[NH4+]
Molecular Formula
C60H80ClN12O14PS
Molecular Weight
1291.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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