PLK1-IN-9

CAT: 0931-T87975-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T87975-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

893772-67-3

Target

PLK

Related Pathways

Cell Cycle/Checkpoint

Bioactivity

PLK1-IN-9 (Compound M2), a polo-like kinase 1 (PLK1) inhibitor, targets the PLK proteins modified with peptides 1010pT, cdc25c, and PBIP, exhibiting IC50 values of 1.6, 0.8, and 1.4 μM, respectively. This compound effectively inhibits the proliferation of various cancer cell lines including HeLa, HL60, SNU387/499, and HepG2, demonstrating cytotoxic effects and inducing apoptosis. Additionally, PLK1-IN-9 has been shown to suppress tumor growth in a HepG2 xenograft mouse model.

Smiles

O=C1N=C2C(=NC=3C=C(C=CC3N2C)C(F)(F)F)C(=O)N1

Molecular Formula

C12H7F3N4O2

Molecular Weight

296.2

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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