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PLK1-IN-13

CAT: 0931-T206596-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206596-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3038489-48-1
Target
Apoptosis, c-Myc, PLK
Related Pathways
Cell Cycle/Checkpoint, Apoptosis
Bioactivity
PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM) . PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML) .
Smiles
C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C=C3)C=4SC(CN5CCN(C)CC5)=NN4)N2)C6CCCC6
Molecular Formula
C29H39N9O2S
Molecular Weight
577.744
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-173212PLK1-IN-13
527088-01PLK1
040171PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13)
MBS6334971-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (AP)
MBS6334974-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (FITC)
MBS6334981-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (PE)
MBS6334973-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (Biotin)
MBS6334972-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (APC)
MBS6334978-01PLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (MaxLight 550)
040171-APCPLK1, CT (PLK1, PLK, Serine/threonine-protein kinase PLK1, Polo-like kinase 1, Serine/threonine-protein kinase 13) (APC) discontinued

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