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PLK1-IN-10

CAT: 0931-T87221-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87221-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2991469-21-5
Target
PLK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
PLK1-IN-10 (Compound 4Bb), an orally active inhibitor of the PLK1 PBD (polo-box domain), inhibits the interaction between PLK1 and the cell division regulator protein 1 (PRC1) and reduces the protein expression of the CDK1-Cyclin B1 complex. Additionally, PLK1-IN-10 interacts with glutathione (GSH), enhancing cellular oxidative stress and promoting cell death [1].
Smiles
S(NCC1=CC=C(F)C=C1)(=O)(=O)C=2C3=C4C(C(=O)N(CCN(C)C)C(=O)C4=CC=C3)=CC2
Molecular Formula
C23H22FN3O4S
Molecular Weight
455.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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