SIK-IN-1

CAT: 0931-T87393-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T87393-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3033846-29-3

Target

AMPK

Related Pathways

Chromatin/Epigenetic, PI3K/Akt/mTOR signaling

Bioactivity

SIK-IN-1 (Compound 53) acts as a potent inhibitor of salt-inducible kinase (SIK), specifically targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.4, and 1.5 nM, respectively. Additionally, it effectively suppresses TNFa release with an IC50 of 0.5 nM and enhances LPS-induced IL-10 release in human macrophages with an EC50 of 4 nM [1].

Smiles

C(#N)C=1N2C(=CN=C2C=CC1NC)C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3

Molecular Formula

C23H24N6OS

Molecular Weight

432.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-161440-01	SIK-IN-1
528263-01	SIK
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HY-161441	SIK-IN-2
DF10345-BP	SIK Peptide
MBS517572-01	SIK, Active
HY-161442	SIK-IN-3
sc-153465	Sik siRNA (m)
abx218584	SIK (pT182) Antibody
sc-270371	Sik siRNA (m2)

SIK-IN-1

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