SIKs-IN-1

CAT: 0931-T78762-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T78762-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2927557-06-8

Target

Others, SIK

Related Pathways

PI3K/Akt/mTOR signaling, Others

Bioactivity

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases anti-inflammatory cytokine IL-10 and decreases pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].

Smiles

C(NC1=C(C)C=CC=C1F)(=O)C=2C(NC3CCC3)=NC(NC4=CC(F)=C(C=C4)N5CCN(C)CC5)=NC2

Molecular Formula

C27H31F2N7O

Molecular Weight

507.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
MBS5820424	SIKs-IN-1
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane
OR312388	1-Phenylbicyclo[1.1.1]pentane
GTR19217879-01	AMPK-α1β1γ1 activator 1

SIKs-IN-1

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