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SIK-IN-2

CAT: 0804-HY-161441Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161441Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS -induced IL-10 release with EC50 of 2 nM in human macrophages[1].
CAS Number
3033846-20-4
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sik-in-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21
Molecular Formula
C22H22N6OS
Molecular Weight
418.51
References & Citations
[1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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