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SIK-IN-2

CAT: 0931-T87394-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87394-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033846-20-4
Target
AMPK
Related Pathways
Chromatin/Epigenetic, PI3K/Akt/mTOR signaling
Bioactivity
SIK-IN-2 (Compound 45) is a potent inhibitor of salt-inducible kinase (SIK), effectively targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.2, and 0.4 nM, respectively. Additionally, it suppresses TNFa release with an IC50 of 0.5 nM and promotes LPS-induced IL-10 release with an EC50 of 2 nM in human macrophages [1].
Smiles
C(#N)C=1N2C(=CN=C2C=CC1N)C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3
Molecular Formula
C22H22N6OS
Molecular Weight
418.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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