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SHP2-IN-23

CAT: 0931-T87389-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87389-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2415989-91-0
Target
ERK, Phosphatase
Related Pathways
Metabolism, MAPK
Bioactivity
SHP2-IN-23 (compound 30) is an orally active inhibitor of SHP2, exhibiting potent activity with an IC50 value of 38 nM and demonstrating favorable pharmacokinetic profiles and in vivo efficacy. Additionally, it robustly inhibits ERK phosphorylation, achieving an IC50 of 5 nM [1].
Smiles
N[C@H]1C2(CC=3C1=CC=CN3)CCN(CC2)C4=NC5=C(N=C4)N=C(SC=6C(Cl)=C(N)N=CC6)C=C5
Molecular Formula
C24H23ClN8S
Molecular Weight
491.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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