PI3Kα-IN-22

CAT: 0931-T87164-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T87164-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2925030-26-6

Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Bioactivity

PI3Kα-IN-22 (Compound 17) is a potent, selective, and orally active inhibitor targeting the PI3Kα H1047R mutation, exhibiting an IC 50 of 1 nM in the pAKT T47D AlphaLISA assay. It has demonstrated the ability to induce tumor regressions in the HCC1954 tumor model in mice [1].

Smiles

[C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2

Molecular Formula

C24H23F2N5O3

Molecular Weight

467.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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BA8725-1	PI3K-IN-22
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PI3Kα-IN-22

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