Nic-15

CAT: 0931-T200271-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T200271-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2896739-91-4

Target

MTOR, PI3K, Akt

Related Pathways

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

Bioactivity

Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.

Smiles

C(=O)([C@H]1[C@@H](CC(CCC=C(C)C)=CC1)C2=C(F)C(F)=CC=C2)C3=C(O)C=CC=C3O

Molecular Formula

C25H26F2O3

Molecular Weight

412.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-159577	Nic-15
MBS5774283	NIC
GTR19152155	Etheno-AP2 (Nic) [ε-AP2 (Nic) ]
BA6119-5.1	NIC-0102
NU-519	UP2 (Nic)
MBS5801304	PA Nic
GTR19152151	TP2 (Nic)
GTR19152148	ApCpp (Nic)
NU-514	AP3 (Nic)
NU-521	GP2 (Nic)

Nic-15

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