Nic-15

CAT: 0931-MF-0142483-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0142483-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2896739-91-4
Target
MTOR|||PI3K|||Akt
Related Pathways
Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling
Bioactivity
Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.
Smiles
C(=O)([C@H]1[C@@H](CC(CCC=C(C)C)=CC1)C2=C(F)C(F)=CC=C2)C3=C(O)C=CC=C3O
Molecular Formula
C25H26F2O3
Molecular Weight
412.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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