MRK-898

• CAS Number :

  461450-30-6

• Target :

  GABA Receptor

• Related Pathways :

  Neuroscience|||Membrane transporter/Ion channel

• Bioactivity :

  MRK-898, an orally active modulator of the GABA (A) receptor, selectively interacts with the ?1, ?2, ?3, and ?5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the ?1-containing receptors of GABA (A) are classified as "sedative, " whereas receptors containing ?2 and/or ?3 are designated as "anxiolytic" subtype (s) [1].

• Smiles :

  C(F)(F)(F)C1=NC=2N(C(=CN2)C3=CC(=C(F)C=C3)C4=C(C#N)C=C(F)C=C4)C=C1

• Molecular Formula :

  C20H9F5N4

• Molecular Weight :

  400.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C