MRK-898

CAT: 0931-T86930-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T86930-01Size:10 mg
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CAS Number
461450-30-6
Target
GABA Receptor
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
MRK-898, an orally active modulator of the GABA (A) receptor, selectively interacts with the ?1, ?2, ?3, and ?5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the ?1-containing receptors of GABA (A) are classified as "sedative, " whereas receptors containing ?2 and/or ?3 are designated as "anxiolytic" subtype (s) [1].
Smiles
C(F)(F)(F)C1=NC=2N(C(=CN2)C3=CC(=C(F)C=C3)C4=C(C#N)C=C(F)C=C4)C=C1
Molecular Formula
C20H9F5N4
Molecular Weight
400.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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