MRK-A

• Description :

  MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors[1].

• UNSPSC :

  12352005

• Target :

  Isocitrate Dehydrogenase (IDH)

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5

• Molecular Formula :

  C28H30N4O2

• Molecular Weight :

  454.56

• References & Citations :

  [1]Kopinja J, et al. A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit. Sci Rep. 2017 Oct 23;7 (1) :13853.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1934301-68-4]