MRK-623

• Target:

  Others|||GABA Receptor

• Related Pathways:

  Neuroscience|||Membrane transporter/Ion channel|||Others

• Bioactivity:

  MRK-623 (Compound 14k) is a potent, orally active agonist of the GABA A receptor with high affinity for subunits ?1, ?2, ?3, and ?5, exhibiting Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM, respectively. Notably, MRK-623 demonstrates anxiolytic effects [1].

• Smiles:

  C(C)(C)(O)C1=NC=2N(C(=CN2)C3=CC(=C(F)C=C3)C=4C=CC=NC4)C=C1

• Molecular Formula:

  C20H17FN4O

• Molecular Weight:

  348.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  461449-78-5