MRK-016

• Target:

  GABA Receptor

• Related Pathways:

  Membrane transporter/Ion channel|||Neuroscience

• Purity:

  0.9976

• Bioactivity:

  MRK-016 is a selective GABAA ?5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects.

• Smiles:

  N=1N=C(C2=NOC(=C2)C)N3N=C(OCC4=NC=NN4C)C(=C3C1)C(C)(C)C

• Molecular Formula:

  C17H20N8O2

• Molecular Weight:

  368.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  342652-67-9