FGFR-IN-13

CAT: 0931-MF-0147574-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0147574-01Size:25 mg
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CAS Number
2962941-25-7
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM) . It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].
Smiles
C(N1C=2C(=C(N=CN2)C3=CC(OC)=CC(OC)=C3)N=C1)C4=CC=C(NC(C=C)=O)C=C4
Molecular Formula
C23H21N5O3
Molecular Weight
415.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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