Divarasib adipate

• Target :

  Kras|||Ras

• Related Pathways :

  MAPK|||GPCR/G Protein

• Bioactivity :

  Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 ?M, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].

• Smiles :

  C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5

• Molecular Formula :

  C35H42ClF4N7O6

• Molecular Weight :

  768.2

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2762240-36-6