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Divarasib

CAT: 0013-GTR19208842-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208842-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Divarasib (GDC-6036) is a potent, selective, and oral KRAS G12C inhibitor with sub-nanomolar IC50, which irreversibly traps the oncoprotein in an inactive state to suppress tumor growth. It is actively researched in vitro and in vivo for treating solid tumors such as non-small cell lung cancer and colorectal cancer.
CAS Number
2417987-45-0
Product Name Alternative
Divarasib, KRAS G12C, GDC6036, GDC-6036, GDC 6036
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.79% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.3 mM) ; DMSO:90 mg/mL (144.68 mM)
Smiles
C[C@H]1CN (CCN1c1nc (OC[C@@H]2CCCN2C) nc2c (F) c (c (Cl) cc12) -c1nc (N) cc (C) c1C (F) (F) F) C (=O) C=C
Molecular Formula
C29H32ClF4N7O2
Molecular Weight
622.06
Storage Conditions
-20°C
Notes
For research use only.

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