CDK8-IN-14

• Target:

  CDK

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01?M in MOLM-13 cells and 0.03±0.01?M in MV4-11 cells [1].

• Smiles:

  C (N) (=O) C=1C=C (C=2C=C3C (=CNC3=NC2) C=4C=COC4) C=CC1

• Molecular Formula:

  C18H13N3O2

• Molecular Weight:

  303.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2924193-12-2