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CARM1-IN-4

CAT: 0931-T86005-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86005-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2878481-07-1
Target
Apoptosis, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, Apoptosis
Bioactivity
CARM1-IN-4 (compound 11f) serves as a potent inhibitor of CARM1, exhibiting IC50 values of 9 nM for CARM1 and 56 nM for PRMT1. This compound significantly inhibits the proliferation of colorectal cancer cell lines and curtails the methyltransferase activity of CARM1, blocking the methylation of downstream proteins. Moreover, CARM1-IN-4 induces apoptosis and demonstrates notable antitumor activity [1].
Smiles
C(OCC)C1(COCC)CCC(OC2=C(CN(C[C@H](CNC)O)C)C=CC=C2)CC1
Molecular Formula
C24H42N2O4
Molecular Weight
422.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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