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CARM1 degrader-1

CAT: 0931-T79741-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79741-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
PROTAC CARM1 degrader-1 (compound 3b) is a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1), facilitating its degradation via the VHL-proteasome pathway. By degrading CARM1, it reduces methylation of substrates, such as poly (A) -binding protein PABP1 and BGR1-associated factor BAF155, inhibiting breast cancer cell migration [1].
Molecular Formula
C71H98N12O8S
Molecular Weight
1279.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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