CARM1 degrader-2

• Target :

  Histone Methyltransferase

• Related Pathways :

  Chromatin/Epigenetic

• Bioactivity :

  PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated arginine methyltransferase (CARM1) . It promotes the degradation of CARM1 and prevents the methylation of its substrates, including poly (A) -binding protein PABP1 and BGR1-associated factor BAF155, consequently inhibiting breast cancer cell migration [1].

• Molecular Formula :

  C72H100N12O7S

• Molecular Weight :

  1277.71

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C