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Anticancer agent 109

CAT: 0931-T85667-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T85667-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2097497-16-8
Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
Anticancer agent 109 (compound 6-15) acts as an inhibitor targeting the Gas6-Axl axis, demonstrating significant anti-cancer properties. This compound suppresses the expression of Gas6, Axl, p-PI3K, and p-AKT in cancer cells, thereby inducing G1 phase arrest and promoting apoptosis of cancer cells. Additionally, Anticancer agent 109 effectively inhibits tumor growth in nude mouse tumor-bearing models [1].
Smiles
C(=C\1/C=2C(NC1=O)=NC(C)=C(O)C2C)\C3=NC4=C(C=C3)C=CC=C4
Molecular Formula
C19H15N3O2
Molecular Weight
317.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Anticancer agent 109
CAS Number2097497-16-8
PubChem CID129116328
IUPAC Name(3Z)-5-hydroxy-4,6-dimethyl-3-(quinolin-2-ylmethylidene)-1H-pyrrolo[2,3-b]pyridin-2-one
Molecular FormulaC19H15N3O2
Molecular Weight317.3
XLogP2.9
Topological Polar Surface Area75.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count24
Formal Charge0
Complexity535
SMILES
CC1=C2/C(=C/C3=NC4=CC=CC=C4C=C3)/C(=O)NC2=NC(=C1O)C
InChI
InChI=1S/C19H15N3O2/c1-10-16-14(19(24)22-18(16)20-11(2)17(10)23)9-13-8-7-12-5-3-4-6-15(12)21-13/h3-9,23H,1-2H3,(H,20,22,24)/b14-9-
InChIKey
CSKXBCHNPARCGH-ZROIWOOFSA-N
Chemical Structure
2D Structure
2D structure of Anticancer agent 109
CAS: 2097497-16-8
CID: 129116328
Formula: C19H15N3O2
MW: 317.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight317.3
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass317.116426730
Monoisotopic Mass317.116426730
Topological Polar Surface Area75.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity535
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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