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CCR4 antagonist 4

CAT: 0931-T84701-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84701-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
668980-17-4
Target
Others, CCR
Related Pathways
Others, Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology
Bioactivity
CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].
Smiles
N(CC1=C(Cl)C=C(Cl)C=C1)C=2C3=C(N=C(N2)N4CCN(C(=O)[C@H]5CCCCN5)CC4)N=CC=C3
Molecular Formula
C24H27Cl2N7O
Molecular Weight
500.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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