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CCR4 antagonist 2

CAT: 0931-T10713-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T10713-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2206788-99-8
Target
Calcium Channel, CCR
Related Pathways
Membrane transporter/Ion channel, GPCR/G Protein, Microbiology/Virology, Immunology/Inflammation, Metabolism
Bioactivity
CCR4 antagonist 2 (Compound 31) is a novel, potent, orally bioavailable small molecule antagonist of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+ flux and [chemotaxis] CTX at 40 nM and 70 nM, respectively.
Smiles
[C@H](C)(N1C=2C(C(C#N)=N1)=NC=C(N2)C=3C[C@@H](C)[C@H](CC3)N4[C@H](CO)CCC4)C5=C(Cl)C=C(Cl)C=C5
Molecular Formula
C26H28Cl2N6O
Molecular Weight
511.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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