KH-4-43

• CAS Number :

  2813310-07-3

• Target :

  E1/E2/E3 Enzyme|||Others

• Related Pathways :

  Others|||Ubiquitination

• Bioactivity :

  KH-4-43, an inhibitor of the E3 CRL4 ligase complex, demonstrates anticancer activity by targeting the core of the E3 CRL4. It exhibits a binding affinity (Kd) of 83 nM to the E3 ROC1-CUL4A CTD and 9.4 ?M to the closely related ROC1-CUL1 CTD [1].

• Smiles :

  C(F)(F)(F)C1=C(C(=O)C=2C(O1)=C(O)C(O)=CC2)C3=CN(N=C3)C4=CC=C(Cl)C=C4

• Molecular Formula :

  C19H10ClF3N2O4

• Molecular Weight :

  422.74

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C